University of Hong Kong
Working Out How Cancer Causing Mutations Form Through Cancer Genome Sequencing
Cancer develops when the genome of cell gains one or more driver mutations that result in malignant transformation. A major goal in cancer genomics and precision oncology is to identify these cancer driver mutations in order to inform patient treatment. However, despite the ability to identify such mutations through next-generation sequencing (NGS), how specific somatic mutational events arise remains poorly understood. In this talk, I will discuss our recent work in using NGS data to improve our understanding of how somatic mutations form. In particular, I will highlight our recent research using mutational signatures derive from the frequency of mutated trinucleotides for investigating associations between the underlying mutational processes that operate in cancer samples and the presence of specific driver mutations. Our research uncovers previously unknown driver-mutational process relationships that can improve our understanding of cancer development and inform new cancer prevention strategies or additional avenues for scientific research.
Dr Wong is an Associate Professor in the School of Biomedical Sciences at the University of Hong Kong. He was formerly an Australian Research Council Future Fellow and remains an honorary Associate Professor at the Prince of Wales Clinical School at the University of New South Wales in Sydney. He got his Irish Government post-doctoral fellowship at the Conway Institute of Biomolecular & Biomedical Research, University College Dublin, specialising in Chemical Proteomics. To date, he has published over 80 original peer-reviewed journal articles and has attracted over $2 million in research funding as lead investigator from the ARC, NHMRC, Cancer Australia and Cancer Institute NSW. His current research is focused on the study of mutational processes in cancer and their ultimate effect on gene regulation and function.